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erβ selective antagonist phtpp  (Tocris)


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    Tocris erβ selective antagonist phtpp
    Erβ Selective Antagonist Phtpp, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 223 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/erβ selective antagonist phtpp/product/Tocris
    Average 94 stars, based on 223 article reviews
    erβ selective antagonist phtpp - by Bioz Stars, 2026-05
    94/100 stars

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    Image Search Results


    Fig. 3. ERα but not ERβ regulates BMS-345541-prevented REMSD-induced allodynia in female rats. A) Effect of intrathecal injection of BMS-345541 pretreatment (preTx BMS 10 µg) in the establishment of mechanical allodynia induced by REM sleep deprivation (REMSD) for two days in intact female rats (F), female rats with vehicle (Veh), rats treated with ICI (ICI+preTx BMS), rats treated with a selective ERα antagonist (MPP+preTx BMS) or rats treated with a selective ERβ antagonist (PHTPP+preTx BMS). B) Area under the curve (AUC) obtained from time course in A. C) Effect of intrathecal injection of BMS-345541 pretreatment (preTx BMS 10 µg) in the establishment of mechanical allodynia induced by REMSD in female rats with vehicle (Veh), non-ovariectomized female rats (F), ovariectomized rats (OVX) and ovariectomized rats in the presence of ERα agonist (OVX+PPT). D) Area under the curve obtained from time course in C. Data are expressed as the mean ± SEM (n = 6). *** p < 0.001 versus Veh group; # # # p < 0.001 versus intact female rats with pretreatment (F) by one-way ANOVA followed by the Tukey test.

    Journal: Brain research

    Article Title: Estrogen receptor α regulates the IKKs/NF-kB activity involved in the development of mechanical allodynia induced by REM sleep deprivation in rats.

    doi: 10.1016/j.brainres.2024.149269

    Figure Lengend Snippet: Fig. 3. ERα but not ERβ regulates BMS-345541-prevented REMSD-induced allodynia in female rats. A) Effect of intrathecal injection of BMS-345541 pretreatment (preTx BMS 10 µg) in the establishment of mechanical allodynia induced by REM sleep deprivation (REMSD) for two days in intact female rats (F), female rats with vehicle (Veh), rats treated with ICI (ICI+preTx BMS), rats treated with a selective ERα antagonist (MPP+preTx BMS) or rats treated with a selective ERβ antagonist (PHTPP+preTx BMS). B) Area under the curve (AUC) obtained from time course in A. C) Effect of intrathecal injection of BMS-345541 pretreatment (preTx BMS 10 µg) in the establishment of mechanical allodynia induced by REMSD in female rats with vehicle (Veh), non-ovariectomized female rats (F), ovariectomized rats (OVX) and ovariectomized rats in the presence of ERα agonist (OVX+PPT). D) Area under the curve obtained from time course in C. Data are expressed as the mean ± SEM (n = 6). *** p < 0.001 versus Veh group; # # # p < 0.001 versus intact female rats with pretreatment (F) by one-way ANOVA followed by the Tukey test.

    Article Snippet: PHTPP [4-[2-fenil-5,7-bis(trifluorometil) pirazolo[1,5-a]-pirimidin-3-il]fenol], a selective ERβ antagonist (Cat. No SC-204191, Santa Cruz Biotecnology, Dallas, TX) and PPT(1,3,5-Tris (4-hydroxyphenyl)-4-propyl-1H-pyrazole), a selective ERα agonist (Cat. No. SC-297946, Santa Cruz Biotechnology, Dallas, TX) were dissolved in 1 % DMSO in saline.

    Techniques: Injection